Date: 1st to 3rd July 2016
Venue: Imperial Riding School Renaissance Vienna Hotel, Vienna, Austria
The summer of 2016 marked the 10th anniversary of the EU-US collaboration to standardize parameters of disease and diagnostics for practice and clinical trials in patients with Myelodysplastic syndromes (MDS). Experts from Europe and the US were brought together to discuss recently discovered cytogenetic, molecular and flow cytometry-based markers that may help in the delineation and prognostication of potential MDS and pre-MDS conditions.
The scene was set by reflecting on the morphology, histological features, patterns and differential diagnosis in MDS. During the day, the experts discussed scoring systems in MDS, cytogenetic and molecular features, application of flow cytometry, as well as treatment approaches in MDS.
The following days were focusing on the minimal diagnostic criteria and prognostication in MDS. Emerging cytogenetic and molecular markers were discussed, followed by pre-MDS conditions and refinements of the morphologic criteria.
The outcomes of this conference, including criteria and a proposal for the classification of pre-MDS conditions as well as updated minimal diagnostic criteria of MDS, were summarized and published in the following year (https://doi.org/10.18632/oncotarget.19008 ) with the aim to facilitate diagnostic and prognostic evaluations in clinical studies as well as in clinical practice.
Working Conference: Biology, Classification and Therapy of Basophil Disorders
Date: 3rd to 4th March 2016
Venue: Research Center for Molecular Medicine of the Austrian Academy of Science (CeMM) Building at the Campus of the Medical University of Vienna, Austria
The LBC ONC has organized a workshop on Biology, Classification and Therapy of Basophil Disorders on March 3rd and 4th, 2016.
The aim of a series of meeting was to bring together experts from all over Europe and to discuss classification of basophilic leukemias.
A highlight of the meeting was a joint microscopy session, chaired by Hans-Peter Horny, a world-famous pathologist.
Due to the rarity of basophilic diseases, criteria for the diagnosis and classification of basophilic leukemias have not been established yet. This is an unmet need for diagnosis, treatment and prognosis for patients suffering from this type of diseases. The effort culminated in this workshop and a publication in a top journal in the field of hematology (Leukemia 2017, DOI: 10.1038/leu.2017.15).
During the meeting, the faculty focused on providing a summary of consensus statements from this and previous meetings with the aim to propose criteria to delineate acute basophilic leukemia (ABL) from chronic basophilic leukemia (CBL) and primary forms of the disease where no preceding myeloid malignancy is detected, from the more common 'secondary' variants. Furthermore, a novel term was proposed: hyperbasophilia (HB) as description for cases with persistent peripheral basophil count (⩾1000 per μl).
The criteria and classification proposed in this meeting should facilitate the diagnosis and management of patients with unexplained basophilia and basophil neoplasms in routine practice and in clinical studies.